Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. To consolidate a wide range of biological and clinically oriented data from this unique kinase in cancer, this systematic review summarises existing knowledge from in vitro, in vivo and pre-clinical studies on CSNK2 across 24 different human cancer types. Clinically, it held prognostic significance across 14 different cancers, and its inhibition in xenograft experiments resulted in a positive treatment response in In conjunction with commentary on preliminary studies of CSNK2 inhibitors in humans, this review harmonises an extensive body of CSNK2 data in cancer and reinforces its emergence as an attractive target for cancer therapy. Continuing to investigate CSNK2 will be crucial to advancing our understanding of CSNK2 biology, and offers the promise of important new discoveries scientifically and clinically.
What Are Anal Glands?
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Dogs can smell like many things, depending on what they have most recently rolled in, but one of the more unpleasant aromas dogs commonly develop is one of fish. If your dog smells like fish, it is probably not because he figured out how to spray himself with Eau de Sardine. A fishy odor is usually the result of secretions from the anal glands. These sacs are full of specialized sweat glands that produce an unpleasant smelling secretion that acts as a scent marker for your dog. When your dog poops, these secretions pass onto the feces, letting other dogs know important chemical information about your dog.
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