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Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Sal-like protein 4 transcription factor SALL4 and B cell-specific Moloney murine leukemia virus integration site 1 BMI-1 gene were reported to cause treatment failure and relapse in several malignancies. This prospective cohort study was carried out on 60 children with ALL as the patient group and 60 age- and sex-matched children as the control group.
Try out PMC Labs and tell us what you think. Learn More. Doublesex is highly conserved and sex-specifically spliced in insect sex-determination pathways, and its alternative splicing AS is regulated by Transformer, an exonic splicing activator, in the model system of Drosophila melanogaster. However, due to the lack of a transformer gene, AS regulation of doublesex remains unclear in Lepidoptera, which contain the economically important silkworm Bombyx mori and thousands of agricultural pests.